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Consequently, ACNs inhibit inflammatory cytokines like tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6

Some studies also vary the lipid so much that the effects observed may be more due to oxidative stress or essential fatty acid deficiency rather than a consequence of microbial metabolism

Other minor effects include [6]: Uneven skin pigmentation Nail pigmentation Facial flushing Headache Alteration of taste More serious side effects are rare and may include [6]: Acute priapism requiring medical intervention Heart palpitations Hematoma Abdominal pain Hyperventilation Dizziness Seizures Melanoma Clinicians caution against the use of melanotan 2 in subjects with body dysmorphic disorders, particularly as related to skin tone

Serum lipid concentrations in patients with major depressive disorder Biol Psychiatry 1996

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