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Statistically, with the average person losing up to 25 pounds within 6 months of starting a GLP-1, this is not as uncommon as youd assume
Metabolic adaptation is one: as you lose weight, your body requires fewer calories, so the same caloric deficit that produced weight loss initially no longer creates a meaningful gap
doi: 10.3945/ajcn.115.121269 159 YiannakouILongMTJacquesPFBeiserAPickeringRTMooreLLet al
What are the benefits of retatrutide vs semaglutide
Less than 3% of clinical trial participants experienced persistent diarrhea beyond week 16, and most of those found it manageable enough to continue treatment
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