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Signs of dehydration: Symptoms such as dizziness, decreased urination, dark urine, rapid heartbeat, or confusion may indicate significant dehydration requiring medical intervention, particularly if gastrointestinal side effects are severe

NCI 2011

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These hormonal fluctuations can impact appetite regulation

While generally safe for healthy adults, its not recommended during pregnancy/breastfeeding, with active liver/kidney disease, or if you have glutathione sensitivity