Insulin and insulin-like receptors have been studied and thought to be linked mechanistically with PCa
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Initially targeted towards Type 2 diabetes, the significant weight loss benefits observed with GLP-1 RAs such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda ) and tirzepatide (Mounjaro) have led to these treatments becoming blockbuster weight management therapies as well as effective diabetes medications
Notably, only one registered clinical study exists to date, which evaluates an implant-based delivery system of Exenatide and is currently in Phase 1 with an Active, not recruiting status (NCT05670379), initiated on December 20, 2024, and expected to conclude by August 2025
Its clinical profile is backed by Phase 3 randomised controlled trials with pre-specified endpoints, peer-reviewed publication, and FDA scrutiny a standard that CJC-1295 and ipamorelin have not yet met for any approved indication