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Diabetes 64 , 25372549 (2015)

Glutathione, a naturally occurring tripeptide, stands at the center of these vital biological processes

Future studies will reveal the applicability of our model, for example, to activate enzymatically inactive glutaredoxins, to alter the sensitivity and responsiveness of glutaredoxin-coupled fluorescent redox sensors, to further address the catalytic mechanism with GSSCys, HEDS and physiological substrates, or to design specific transition-state inhibitors