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Semaglutide, a GLP-1 receptor agonist approved by the FDA for type 2 diabetes (Ozempic) and chronic weight management (Wegovy), works through mechanisms that overlap with the physiological changes produced by sleeve gastrectomy

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GLP-1 drugs imitate an assortment of gut hormones involved in metabolism and act on the body in myriad ways

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For example, in alveolar macrophages, GLP-1 receptor agonism suppressed activation of the NLRP3 inflammasome and reduced production of IL-1 [65], an effect in part mediated by the disruption of histone lactylation, a recognised regulator of pro-fibrotic gene expression [65]