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These genes include BRD4 23 , BIRC5 /survivin 24 , COX2 13 , EGFR 14 , EFNA3 15 , ERBB2 16 , EYA4A 17 , HIF1A 18 , MAF 19 , LATS1/2 20 , MEIS1 21 , RASSF1A 25 , SOX9 26 , STAT3 18 , STAT5 23 , TAGLN 24 , TCTP 27 , TOP2A 28 , TYK2 29 , WNT 30 , and WT1 31

21 FDA (2022)

In vitro studies have examined its interaction with fibroblast and keratinocyte cell preparations, documenting that the GHK-Cu complex stimulates collagen synthesis in cultured fibroblasts independently of changes in cell number [1], and that GHK-Cu increases matrix metalloproteinase-2 (MMP-2) protein and mRNA levels in fibroblast cultures

Thereby, this observation excludes the significant contribution of enhanced lipid export to the Ex-4-induced steatosis reduction

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