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Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression

Common side effects include gastrointestinal problems, like stomach pain, nausea, and vomiting

Not all patients qualify, and prescriptions are not guaranteed

Fatigue is another area where the gap between trial data and patient experience is meaningful

The study of 333,687 veterans compared 132,551 participants who were prescribed GLP-1s for their type 2 diabetes with 201,136 participants who were prescribed sulfonylureas, another treatment for diabetes, and followed the patients outcomes for up to three years