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Studies have described that flavonols and their derivatives are likely the substrate for GSTLs, which tightly bind to these small molecules ( Arabidopsis and wheat Lambda class GSTs ( AtGSTL1, TaGSTL1 , and TaGSTL3) have been identified to be localized in cytosol, whereas others ( AtGSTL2 and TaGSTL2) are chloroplast localized (Theodoulou et al., 2003)

Acta Physiol (Oxf)

Pain is a prominent example

That's a compromised gut lining

For subcutaneous injection protocols, the concern is indirect: iron-induced copper depletion over weeks could lower the copper available for endogenous GHK-Cu (the body produces approximately 200 g/L of GHK in plasma that declines with age) [1]