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Activation of this circuit in obese mice reduces food intake and improves glucose tolerance by stimulating insulin secretion via inhibition of GABA-input-dependent sympathetic nervous activity in the paraventricular hypothalamus
investigated the proximal signaling cascade and found that the mitochondrial phosphatase phosphoglycerate mutase family member 5 (PGAM5) is also involved in various pathways of regulated necrosis via interaction with another mitochondria-related protein dynamin-related protein 1 (Drp1) [213, 214]
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