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However, some studies suggest tirzepatide may produce greater average weight loss because it targets two hormones involved in appetite regulation instead of one.

10.1016/j.ejphar.2015.05.068 48 KumarA.EkavaliMishraJ.MishraJ.ChopraK.DhullD

Both these studies, from Italy and Spain, showed also how the characteristics of patients treated with GLP-1RAs were markedly influenced by local reimbursement criteria (eg, specific HbA1c or BMI, criteria, etc.) more than changes in guideline recommendations

Research comparing fasted vs fed administration of NNMT inhibitors consistently shows 3040% lower fat oxidation rates in fed-state protocols, even with identical doses