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During the early inflammatory phase, no joint swelling was observed in CIA mice, and metabolic changes mainly involved arginine biosynthesis, arginine/proline metabolism, phenylalanine/tyrosine/tryptophan biosynthesis, and GSH metabolism

Aches during this period typically resolve on their own

Their complementary strengths highlight the need for personalized treatment strategies

We looked into the brain as it is widely recognized as a key regulator of whole-body glucose metabolism

Additionally, research should explore the role of serum GR in the diagnosis and management of related diseases to provide a more comprehensive understanding of its clinical relevance