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Molecular and functional features of tumor blood vessels While physiological blood vessels formation occurring during development, menstrual cycle or wound healing is a tightly controlled process that ceases when the need for new blood vessels have been met, tumor angiogenesis is deregulated due to a persistence of pro-angiogenic factors in the tumor microenvironment
TXNRDs catalyze the reduction of a wide range of substrates, including thioredoxin and protein disulfide isomerase (PDI) (see Figure 2b )
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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
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