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We then compared the PK following subcutaneous administration of four treatment regimens: (i) repeated daily 20 g injections of Sema in a saline vehicle to mimic current clinical practice, [48] (ii) single PNP Sema hydrogel formulations, (iii) single PNP TZP hydrogel formulations, and (iv) repeated daily PBS injections as an untreated control (5 n 6 for each treatment group)

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