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498 The key pathological features of AD are the accumulation of A-enriched neuritic plaques and neurofibrillary tangles (NFTs) (consisting of tau protein)
The elevations of ROS levels in the Cgatg1 strain by these three ROS-generating agents were mild (approximately 10- to 15-fold relative to the control), while H 2 O 2 markedly elevated the ROS level in the Cgatg1 strain (over 60-fold relative to the control)
This quantal dose-response phenomenon is used to determine the median lethal dose ( LD 50 ) of drugs, as defined in Figure 41
34 DixonS
doi: 10.1111/j.1600-0854.2009.00966.x 42 SchraderMFahimiHD
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