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Nrf2-dependent antioxidant pathway Allicin was also found to upregulate the expression of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis, and other Phase II detoxifying/antioxidant enzymes, likely via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway (19)

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revealed the incorporation of 13 C label from labelled acetyl-l-carnitine into glutamate and GABA neurotransmitters, suggesting that acetyl-l-carnitine was used as a substrate for their biosynthesis [25]

Dietary l-carnitine efficiently increased the free carnitine and acyl-carnitine concentrations in the serum and liver of the low-carnitine tilapia, and also reduced lipid accumulation in tissues of the low-carnitine tilapia