In these PD models, sitagliptin and liraglutide improved motor activity, preserved nigral cell death, increased GDNF levels, but, interestingly, they markedly decreased proinflammatory cytokines, probably by inhibiting the AMPK/NF-kB signaling pathway
These results suggest that TR might transcriptionally controls the Cyp8b1 expression through a super-enhancer-mediated mechanism
These people are also sensitive to other thiols like glutathione, and NAC, and stuff like that
The trial data shows slightly higher hair loss rates with tirzepatide (about 5%) versus semaglutide (about 3%), but tirzepatide also produces more weight loss, which to me is the more likely explanation
How Semaglutide Works (In Simple Terms) Semaglutide works by copying a natural hormone in your body (GLP-1) that helps control blood sugar and appetite