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A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss
the elderly, strict vegetarians (i.e., vegan), and patients with malabsorption problems are more likely to become deficient
Early warning signs include dark yellow urine, dry mouth, headache, dizziness when you stand up, and unusual fatigue beyond what the day so far justifies
Postiglione A, Soricelli A, Cicerano U, et al
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