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Gastric Motility and Gastrointestinal Research Cagrilintide's pronounced effects on gastric emptying make it valuable for studying gastrointestinal physiology [5] : Gastric Emptying Studies: Quantification of dose-response relationships between amylin receptor activation and gastric motor function Nutrient Sensing: Investigation of how delayed gastric emptying affects incretin secretion and glucose-dependent insulinotropic polypeptide (GIP) responses Satiety Signaling: Exploration of the relationship between mechanical gastric distension, vagal signaling, and central satiety pathways 5

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For the inhibition assay, the concentrations of substrates in the cell lysate treated with different concentrations of inhibitors were determined via LC-MS, and the calculation methods for the uptake rate and UR were similar to those in the substrate assay

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