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This subset has distinct characteristics: Clinical pattern: Constipation begins in the first 4-8 weeks (typical) Symptoms plateau but don't improve after 12-16 weeks at stable dose Requires ongoing daily laxative use (usually polyethylene glycol) Worsens with dose escalation and improves with dose reduction Resolves within 2-4 weeks of discontinuing medication Why this happens: The current hypothesis is inadequate compensatory upregulation of non-GLP-1 motility pathways
Cagrilintide is a long-acting amylin peptide from Novo Nordisk that mimics the fullness hormone your body makes after meals
Ivanov, T
Physicians prescribing these compounds now operate without a clear compounding framework
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