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Moreover, the pharmacokinetics of injected GLP-1 RAs can be a limitation, necessitating frequent dosing schedules that may deter long-term use
Clinical data insights: In a large placebo-controlled trial, tesamorelin raised IGF-1 by 181% on average, but about 5% of participants discontinued due to adverse events, most commonly musculoskeletal pain and injection-site irritation (Falutz et al., NEJM )
Source: Sikiric et al., Curr Pharm Des 2018
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