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If a patient has not achieved at least 5% weight loss by this point, the benefit-risk profile should be reevaluated

Decoding the implications of glucagon-like peptide-1 receptor agonists on accelerated 4 facial and skin aging

van Greevenbroek MM, Schalkwijk CG, Stehouwer CD

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Adiposity, particularly visceral adiposity, is among the most potent drivers of what geroscientists call the "hallmarks of aging," including chronic low-grade inflammation, mitochondrial dysfunction, cellular senescence, and dysregulated nutrient sensing [7]