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S-Acetylglutathione (SAG) is a GSH precursor, it is more stable than GSH itself in plasma and is taken up directly by cells and later converted to GSH (see Figure 1)

Safety concerns with IV glutathione for skin lightening: Side effects including skin rashes, abdominal pain, thyroid dysfunction, liver dysfunction, kidney dysfunction, and possible kidney failure have been reported with intravenous glutathione injections [60]

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The renal impairment study excluded participants who required dialysis and while renal clearance is a focus of this study, this can be seen as a limitation