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(2010) Hormonal and metabolic effects of morning or evening administration of vildagliptin in patients with type 2 diabetes, Clinical Drug Investigation , 30(11), pp

The trade-offs include unpredictable absorption affected by food intake, stomach pH, and gastrointestinal health conditions like acid reflux or irritable bowel syndrome

On a pen for 0.25/0.5 mg doses, -0-, 0.25 and 0.5 dosages should eb the only doses shown when dialed to the intended dose

doi: 10.1007/s11011-021-00673-z 61 KulasJAWeigelTKFerrisHA

In these separate phase 3 trials, gastrointestinal side effects were reported more frequently with the highest dose of retatrutide than with tirzepatide