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Once-weekly semaglutide 7.2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial. The Lancet 2025 # # #Semaglutide # # #

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This is why a gradual dose escalation schedule is recommended

Yes, it is strongly recommended to follow cycles (e.g., 12 weeks on followed by 4 weeks off) to avoid receptor desensitization and to allow the endocrine system to function normally

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