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Under normal conditions, Nrf2 is anchored in the cytosol through its interaction with Kelch-like ECH-associated protein 1 (Keap1), which serves as a substrate adapter protein for an E3 ubiquitin ligase complex (Zhang et al

Animals and diets Male C57BL/6J mice (5 weeks old, 2024 g) were purchased from The Jackson Laboratory (Bar Harbor, ME) and acclimatized in the Institutional Animal house for one week