First, a recent study showed that GIPR antagonism reduces insulin secretion during a meal-tolerance test in subjects with T2D 37,38
( C ) GO term analysis showing the biological processes enriched in the -1 subcluster
Regular consultations ensure that any adverse effects are addressed promptly and medication doses are adjusted as needed for safety and effectiveness
For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80
Musumeci T, Bonaccorso A, De Gaetano F, Larsen KL, Pignatello R, Mazzaglia A, et al