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For example, extracellular DNA at normally non-immunogenic concentrations can gain immunogenic properties when binding to HMGB1, then activate TLR9 which ultimately leads to pyroptosis and the release of more DNA and HMGB1

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Satarker et al., 2022)

These findings imply that emodin protects hepatocytes from APAP-induced liver damage by activating Nrf2-mediated antioxidant stress pathways, inhibiting the NLRP3 inflammasome, and downregulating the cGAS-STING signaling pathway (Shen et al., 2022)

doi:10.1080/00498250600621627