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Upon entering target cells, GCs bind to the glucocorticoid receptor (GR), which then translocates into the nucleus to modulate gene transcription [23]

370,371,372 Thus, insulin signaling likely also carries important and diverse roles in brain functioning and AD pathogenesis

Conclusion TMQ0153 targets mitochondrial dynamics by inhibiting OPA1, inducing metabolic reprogramming, and triggering apoptosis in AML cells

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