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The primary endpoint is a renal composite episode defined by a decrease in GFR 50%, end-stage renal failure, and death from a renal-cause or cardiovascular-caused death, and it is scheduled for completion in 2024

Ex-4 also reverses the high-fat-diet-induced impairment of brain-derived neurotrophic factor (BDNF) signaling and the inflammatory response in the 3xTg-AD mouse model [76]

Mol Metab 85:101960 Kanoski SE et al (2011) Hippocampal leptin signaling reduces food intake and modulates food-related memory processing

Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

These alterations are thought to impact gut barrier integrity and immune function, both of which are implicated in CFS/ME pathophysiology