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Alterations in the microbial flora, gut inflammation, increased intestinal barrier permeability (forming a leaky gut), bacterial translocation, and exposure to stressful environments in schizophrenia (144, 152, 156), may trigger innate immunity via TLR4 stimulation
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To further support the evolutionary role of ADH5 in preventing FA toxicity, we carried out a phylogenetic analysis in eukaryotes looking for genes coding for ADH5-like proteins (Fig
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