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Lifestyle Modifications : For long-term success, medication must be accompanied by a commitment to lifestyle changes , such as: Reducing carbohydrate intake : A lower-carb diet helps your body burn fat more effectively

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Garetosmab, activin A inhibitor antibody for muscle-preservation combination regimens in obesity Recent Highlights: In June 2026, the company announced it would present new clinical data from the Phase 2 COURAGE trial that examines the effects of trevogrumab (anti-GDF8) on lean mass in people with obesity treated with semaglutide

It is also FDA approved to lower the risk of heart and kidney problems in people with diabetes, heart failure, or kidney disease