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It can also upregulate Bax and downregulate Bcl-2 to inhibit the progression of the cell cycle from the G1 phase to the S phase, causing tumor cells to stay in the G1 phase and increasing DNA vulnerability to damage (166)

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Similarly, Iron-coordinated polymer nanoparticles (PCFD) further integrate doxorubicin (DOX) and cinnamaldehyde (CA) to disrupt redox homeostasis through triple mechanisms: Fe + -mediated GSH depletion, DOX-induced ROS generation, and CA-enhanced oxidative stress (202)

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Diet sodas often contain caffeine, which can disturb sleep in some people