Molecular Properties Property Value Systematic Name Aib-His-D-2-Nal-D-Phe-Lys-NH Molecular Formula CHNO Molecular Weight 711.85 Da CAS Number 170851-70-4 Structure Class Synthetic pentapeptide Receptor Target GHS-R1a (growth hormone secretagogue receptor type 1a) Development Novo Nordisk (NNC 26-0161) The sequence includes -aminoisobutyric acid (Aib) at position 1, D-2-naphthylalanine (D-2-Nal) at position 3, and D-phenylalanine (D-Phe) at position 4
They are not FDA-approved for safety, effectiveness, or quality
Current pregnancy, breastfeeding, and active conception planning are screened directly because this class of therapy is not appropriate during those windows
The number of stand-alone PDPs has been declining (464 PDPs nationwide in 2025, down 35% from the year prior), as more beneficiaries opt for MA-PD plans ( [7] )
The PBAC will discuss this issue at its November 2025 meeting and provide advice to the Minister by end 2025. In a separate notification, the TGA also flagged it has issued 10 infringement notices to telehealth operator Midnight Health Pty Ltd for the alleged unlawful advertising of prescription-only weight-loss medicines