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Eli Lilly submitted the orforglipron NDA to the FDA in Q1 2026 following ATTAIN Phase 3 trial data showing 14.7% body weight reduction at 45mg positioning the worlds first oral small molecule GLP-1 receptor agonist for obesity for anticipated FDA approval in late 2026 or 2027

Liver, spleen, and kidney are the typical organs examined in the DC mouse model

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Tschakovsky ME, Joyner MJ: Nitric oxide and muscle blood flow in exercise