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The requirement of two distinct glutathione interaction sites for the efficient reduction of GSSR by GSH explains the deviating properties and substrate preferences of glutaredoxin subfamilies as well as thioredoxins with implications for the design and optimization of artificial enzymes and inhibitors

Finally, we discuss how targeting the CoQ 10 redox network may provide a clinically actionable strategy to exploit ferroptosis vulnerabilities in cancer

Pentadeca Arginate (PDA) is a synthetic peptide composed of 15 amino acids, recognized for its regenerative and healing properties

2026 Jan 22;189(2):640-658.e22

Its nearly 100%