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Receptor Selectivity 5-Amino 1MQ demonstrates high selectivity for NNMT, avoiding off-target effects: [3] Does NOT inhibit structurally related SAM-dependent methyltransferases: DNMT1, PRMT3, COMT Does NOT inhibit NAD+ pathway enzymes: NAMPT, SIRT1 This confirms that NAD+ and SAM increases result solely from preventing their degradation by NNMT, not from interfering with their synthesis or utilization enzymes

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Individuals with active cancer or a history of malignancy should avoid the peptide unless under medical supervision, as effects on tumor growth have not been adequately studied