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They synthesized a novel zwitterionic copolymer, poly(MPC-co-FPEMA), via RAFT polymerization and modified it by conjugating tetraphenylethene (TPE), an AIE chromophore, through hydrazone bonds, forming PMPC-hyd-TPE

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In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier

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While oral supplements are an option, they still have to go through the digestive system, where absorption issues can get in the way