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Likewise, no effect was observed on downstream components of the Insulin/IGF-1 signaling pathway with mAb treatment in females (Supplementary Fig 3), but L2-Cmu attenuated S6 activation in male hypothalamus (Supplementary Fig 4c

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The increased lysine detected in the sea urchins in the present study supports the metabolic shift towards protein catabolism and an adaptive stress response, rather than protein synthesis