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While methylcobalamin, the more active form of B12, is ideal for many, hydroxocobalamin can be better tolerated for those folks that feel overly activated, agitated, or anxious with the more active form of B12
This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation
Vegetarians, older adults, and those with absorption issues are at higher risk
Its also important for the production of red blood cells and steroid hormones
Failing any of these six = high risk
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