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Studies on periodontal disease models show the peptide significantly reduced plasma extravasation, histological alterations, and alveolar bone resorption
In the DELTA 1 and DELTA 2 phase 3 trials, delgocitinib cream (20 mg/g) applied twice daily significantly significantly improved IGA-CHE scores compared with vehicle, with 19.729.1% of patients achieving clear or almost clear skin, respectively, versus 6.99.9% in the vehicle groups [103, 106]
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Compound-Level Evidence GHK-Cu A 2018 review in the International Journal of Molecular Sciences synthesized gene-expression data showing GHK-Cu modulates over 4,000 human genes (Pickart and Margolina)
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