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The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

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The shedding typically appears 2 to 3 months after the triggering stressor, which is why many patients on GLP-1 injections notice hair thinning a few months after starting treatment or after a dose increase

However, results vary, and it's important to discuss expectations with a healthcare provider

Reported side effects are typically mild and transient: BPC-157: Nausea (rare), mild fatigue in the first week, minor injection site redness TB-500: Mild lethargy during the loading phase, transient head rush immediately after injection, injection site discomfort Combined stack: No documented synergistic toxicity in preclinical or clinical observational data The more significant risks relate to sourcing and administration rather than the peptides themselves