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A large trial reported in 1994 (pdf) that daily megadoses of the antioxidant beta-carotene increased the risk of lung cancer in male smokers by 18 percent and a 1996 trial was stopped early after researchers discovered that high-dose beta-carotene and retinol, another form of vitamin A, increased lung cancer risk by 28 percent in smokers and workers exposed to asbestos

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Compared with male ApoE / mice, female ApoE / mice exhibited pronounced flavin monooxygenase 3 (FMO3) activity and significantly elevated plasma TMAO levels