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The very low rate constants for direct, glutathione-independent dithiol-disulfide exchange reactions between glutaredoxins and roGFP2 or other protein(S 2 )/protein(SH) 2 couples (despite favorable thermodynamics) are a prerequisite and great advantage for reliable redox measurements in vivo
However, a small percentage of the medicationusually about 5% to 10%is processed through a different pathway involving a specific enzyme
After a recovery period of 14 days postsurgery, the mice received either intraplantar or intraperitoneal administration (20 or 200 L, respectively) of vehicle, exendin 939, or exendin 2029
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May 7, 2025
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