Oxygen and glucose deprivation (OGD) mimics ischemic stroke-induced hyper-permeability of HBMECs due to internalization of VE-cadherin and is dependent on activation of the RhoA/Rock pathway (Chen et al., 2+ in BECs and pericytes and was correlated with the loss of TJs, AJs, increased BBB permeability, and pericyte death (Imai et al., 2019)
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Proinflammatory mediators such as interleukin-6 (IL-6), interleukin-1 (IL-1), and LPS have also been reported to directly stimulate GLP-1 secretion from intestinal endocrine L cells
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