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The altered gastric emptying and potential changes in food intake associated with semaglutide therapy may affect the absorption and metabolism of warfarin, potentially leading to fluctuations in international normalized ratio values

Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses

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Lee E, et al

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