Furthermore, by addressing metabolic dysfunction in obese patients, whose prevalence is increasing in the IBD population (13), GLP-1 RAs could indirectly mitigate inflammation by decreasing the pro-inflammatory activity of adipose tissue, particularly visceral adipose one
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Yet, in many countries the devices being used to deliver GLP-1s are the same for both the weight loss and T2D populations and, in many cases, were originally designed for delivering insulin, such as Novo Nordisks FlexTouch pen (Wegovy, semaglutide) or Eli Lillys KwikPen (Mounjaro, tirzepatide) outside the US
Some researchers add berberine during drug holidays for its blood sugar regulating properties, though this should be discussed with a healthcare provider
Commonly reported adverse effects include: Injection site reactions (redness, pain, swelling) Fluid retention (peripheral oedema, joint pain, or carpal tunnel syndrome) related to GH-mediated effects Glucose metabolism changes : tesamorelin can raise blood glucose levels and may worsen insulin resistance
