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Animal models extend further, with 90-day rat toxicology data published in 2021 showing no organ damage at doses up to 50mg/kg daily, but extrapolating rodent data to human long-term safety requires caution we don't take lightly
Contact your GP or NHS 111 if diarrhoea persists beyond 7 days, contains blood or mucus, accompanies severe abdominal pain, or occurs with unexplained weight loss
The specific day does not matter physiologically
It offers a simple way to manage B12 needs and often works well to address deficiencies caused by diet
For musculoskeletal indications, the guideline is progressive load reintroduction starting no earlier than 6 to 8 weeks, with full training not before 3 months for significant tendon injuries regardless of how good the patient feels
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