Most clinical trials have looked at weight loss and blood sugar control
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Melanotan II is not FDA-approved and may not be appropriate for everyone
(or 0.16 g/mL per-oral) given concurrently with 12.5 mg/kg/day diclofenac in Wistar rats directionally counteracted diclofenac-induced gastric, intestinal, and hepatic lesions and reduced elevations in bilirubin, AST, and ALT though the abstract does not report numeric magnitudes or p-values
This gradual titration is designed to minimise gastrointestinal side effects, but it also allows the body time to adjust metabolically