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For many patients, the challenge isn't just the weight itself, but the underlying insulin resistance and fluctuating blood sugar that drive constant hunger

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Injection site reactions occur in roughly 5% to 8% of users for both peptides

This is because liking a food is different from wanting it , says John Blundell, an emeritus professor in psychobiology at the University of Leeds in England, who was not involved in the recent paper

Rybelsus is semaglutide in oral form, while Ozempic and Wegovy are typically dispensed in prefilled injection pens